Sounds scary; we’re not yet able to reproduce that behavior, here.
Confirming: In Preferences —> General —> Most Recent, is yours set to show the Home screen (the default behavior), or have you changed the pref to “open most recent”?
An error occurred while saving the commentBernard Kotze commented
Found a similar issue(on Windows). Realised that my After Effects update wiped my custom saved workspaces. Premiere Pro didn't but I was unable to drag items around in my project folders and certain windows stopped responding to shortcuts. After rebuilding the workspace and saving as a new one, all functionality has been restored.