Currently, I can’t use Premiere Pro and Audition simultaneously in part because they try to have exclusive control of both the audio interface and MIDI control surfaces.

The user sees a dialog box saying that the audio hardware has changed and the audio interface no longer works in one application. The control surface doesn’t work in the second application.

Audition and Premiere Pro should be able to work side-by-side with device ownership following focus.

Competing DAWs such as Studio One have a preference checkbox that releases the audio interface when it loses focus, which resolves at least the audio side of this problem.