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Is the audio choppy only while After Effects is rendering previews, or after the composition is cached in RAM and playing back?

While After Effects is rendering a preview, audio playback may be choppy or slowed down, as playback at this point may not be real-time.

Once the preview is rendered and cached (the rendered frames are represented by green marks in the Timeline panel), playback should be real-time and audio playback should be smooth.

You can determine whether or not playback is real-time in the Info panel.

If the problem is only that audio is not smooth while previews are being rendered, you can disable audio during rendering in a couple of different ways:
- In the Preview panel, enable the Cache Before Playback option. This causes After Effects to not attempt playback during the rendering stage, which may be more desirable if your comps take longer than real-time to render. (Note that this option, like all options in the Preview panel, are attached to the keyboard shortcut selected in the Shortcut menu of the Preview panel. i.e., If you change the Shortcut option, you can set an entirely different set of behaviors for previews you press that key.)
- In Preferences > Previews, enable the Mute Audio When Preview Is Not Real-time option. This prevents After Effects from playing audio when playback drops below real-time. (Which, again, is a common condition while After Effects is rendering previews.)

If the audio playback problem persists while cached previews are playing back in real-time, we will need to troubleshoot this you. That is more easily done by our support team than on this UserVoice site. You can open a case with them via call or chat at this link: https://helpx.adobe.com/contact.html