Every year, the first update in the new year breaks my custom workspaces, any shortcuts I had to the program, and the program-specific macros that I have set up...because for some reason, Adobe has decided that the install folder must have a year in it, and that year must match the current year.

So once a year, before I get any work done, I have to first sit down and fix all my shortcuts, macros, and workspaces.