Eye Dropper/Color Picker hasn't worked on 4K display for years!
Eye dropper color picker in any of the tools or effects has not worked on my 4K monitor for the last 2 years. When I try to pick a color its like it picks a color from somewhere else on the monitor or often picks black. I have to export a still import into photosshop and pick the color there. I have a Sharp PNK321 LCD display with a Apple Cinema Display also connected and mirrored.

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Olivier Trudel-Languedoc commented
I am running in the same issue. Seems that there is a general issue with Eye Dropper across the app. And removing the UI scaling on the screen makes the app UI too small to work on a 4k monitor. These seems to be a long standing issue that hasnt been looked at.
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Daryl Pritchard commented
Finally! Maybe I have the answer I needed after a Google search with the right search terms led me not only here, but also to this page in the Adobe Support Community: https://community.adobe.com/t5/premiere-pro/color-picker-in-premiere-pro-selects-the-wrong-color/m-p/11722194
What I found among solutions I'd not tried, was someone spoke of the NVIDIA Control Panel and the setting for "user program to control color". While I didn't find such a setting, I did find under "3D Settings/Adjust image settings with preview" that selecting "Let the 3D application decide" seems to have resolved the problems I'd seen.
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Vinko Lukac commented
I have the same problem. My main monitor is 4K resolution with recommended scaling of 150%, the second monitor is 2.7K with recommended scaling of 100% and the third monitor is HD with recommended scaling of 100%. With the given configuration the Eye Dropper/Color Picker tool doesn't work, although if all scalings are set to 100%, the tool works. This problem is only present in Adobe Premiere, in any other program (DaVinci Resolve, Adobe Photoshop) I can't reproduce this issue.
When could this problem be solved?
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Benjamin Bettenhausen commented
Yes I have this problem now with Premiere Pro CC v.14.7.0 but I never had it before with the same system for 2 years. I've found two work-arounds: place all the PP window panes / panels onto the main monitor (Window -> Workspaces -> Editing) or you can right-click on your desktop, select Display Settings, and set scaling (text, icons, and apps) to 100%.
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TaranVH commented
It's because of UI scaling. If you set it to 100%, the issue is resolved.
But then you have a much bigger problem.
Or should I say, SMALLER, har har.